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GoodRx Guide

What Are Cold Sores?

Comprehensive information for you or a loved one — including treatment options and discounts on popular medications.

Cold sores are caused by a herpes simplex virus, herpes labialis. They occur on or around the mouth, and can also be transmitted to the genital area. The sores are painful blisters that leak fluid then crust over, and they can be accompanied by inflammation of the mouth, feversore throat, and other symptoms.

There are a variety of treatments for cold sores. Over-the-counter creams are available, and some prescription drugs used to treat cold sores include herpes virus nucleoside analogues (ValtrexDenavirFamvir) and herpes virus nucleoside analogue / corticosteroid combinations (Xerese).

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